重组人 LF蛋白(His标记) - 其他蛋白 - 江苏先丰纳米材料科技有限公司|高品质石墨烯,黑磷,碳纳米管,等纳米材料制造商和技术服务商

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重组人 LF蛋白(His标记)

货号：106434 编号：XFBM485

CAS号：规格：LF, TRFL, LTF, GIG12

包装：10 μg 保质期：365天

保存条件：-20℃保存

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DESCRIPTION
Gene Name Synonym	LF, TRFL, LTF, GIG12
Species	Human
Accession	P02788
Source	HEK293 cells
SPECIFICATIONS
Amino acid sequence	Gly20-Lys710 is expressed with a 10×His tag at the C terminus
Molecular Weight	79.3 kDa
Purity	>95.0% as determined by SDS-PAGE
Endotoxin	<5 EU mg^-1
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization.
Reconstitution	Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation.
STORAGE
Stability and Storage	12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
BACKGROUND
Lactoferrin (LF) is a multifunctional protein occurring in many biological secretions including milk. It possesses iron binding/transferring, antibacterial, antiviral, antifungal, anti-inflammatory and anti-carcinogenic properties. LF is primarily extracted from bovine milk and it is subsequently added into many commercial products such as nutritional supplements, infant formula, cosmetics and toothpaste. Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands. Although the mechanism underlying the action of Lf in bone cells is still not fully elucidated, it has been shown that its mode of action leading to the survival of osteoblasts is complemented by its mitogenic effect. LF is sensitive to denaturation induced by temperature and other physicochemical stresses. The bioavailability of LF in vivo is poor.
Data
SDS-PAGE		Bioactivity

Recombinant Human LF Protein was determined by SDS-PAGE with Coomassie Blue.		Measured by its ability to induce TNF-α secretion by THP-1 cells. The ED50 for this effect is 31 μg/mL.