重组小鼠CD80 蛋白（His标记）
货号：106462 编号：XFBM470
CAS号： 规格：CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
包装：10 μg 保质期：365天
保存条件：-20℃保存
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DESCRIPTION | ||
Gene Name Synonym | CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7 | |
Species | Mouse | |
Accession | Q00609 | |
Source | HEK293 cells | |
SPECIFICATIONS | ||
Amino acid sequence | Val38-Lys245 is expressed with a 10×His tag at the C terminus | |
Molecular Weight | 25.1 kDa | |
Purity | >95.0% as determined by SDS-PAGE | |
Endotoxin | <5 EU·mg-1 | |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. | |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. | |
STORAGE | ||
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. | |
BACKGROUND | ||
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. | ||
Data | ||
SDS-PAGE | Bioactivity | |
| Testing in progress | |
Recombinant Mouse CD80 Protein was determined by SDS-PAGE with Coomassie Blue, showing bands at 40-50 and 65-90 kDa. | ||
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