重组人 PCT蛋白
货号：106466 编号：XFBM493
CAS号： 规格：CALCA, calcitonin related polypeptide alpha, CGRP, CGRP1, CT, katacalcin, KC, Procalcitonin, PCT
包装：10 μg 保质期：365天
保存条件：-20℃保存
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DESCRIPTION | |
Gene Name Synonym | CALCA, calcitonin related polypeptide alpha, CGRP, CGRP1, CT, katacalcin, KC, Procalcitonin, PCT |
Species | Human |
Accession | P01258 |
Source | E.coli |
SPECIFICATIONS | |
Amino acid sequence | E.coli-derived Human Procalcitonin protein, Ala26-Asn141. |
Molecular Weight | Approximately 13.0 kDa. |
Purity | >95.0% as determined by SDS-PAGE. |
Endotoxin | <1.0 EU/μg of the protein by the LAL method. |
Formulation | Lyophilized from sterile Tris-Hcl, pH 8.0. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. |
STORAGE | |
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. |
BACKGROUND | |
Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus, which is subsequently cleaved into three parts : a 57 aa pro-region, a 32 aa Calcitonin peptide and a 21 aa Katacalcin peptide. PCT is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. PCT is considered to be one of the earliest and most specific markers of sepsis. | |
Data | |
SDS-PAGE | Bioactivity |
| Testing in progress |
Recombinant Human PCT Protein was determined by SDS-PAGE with Coomassie Blue. | |
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