重组人SIRP alpha(CD172A) 蛋白 （His-tag）
货号：106476 编号：XFBM472
CAS号： 规格：CD172a, BIT; MFR, MYD1, MYD-1, P84, PTPNS1, SHPS1, SHPS-1
包装：10 μg 保质期：365天
保存条件：-20℃保存
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DESCRIPTION | ||
Gene Name Synonym | CD172a, BIT; MFR, MYD1, MYD-1, P84, PTPNS1, SHPS1, SHPS-1, SHPS1CD172A, SIRPA, Sirp-alpha-1, SIRPalpha2, Sirp-alpha-2, Sirp-alpha-3 | |
Species | Human | |
Accession | P78324 | |
Source | HEK293 cells | |
SPECIFICATIONS | ||
Amino acid sequence | Glu31-Tyr373 is expressed with a 11×His tag at the C terminus | |
Molecular Weight | 37.8 kDa | |
Purity | >95.0% as determined by SDS-PAGE | |
Endotoxin | <5 EU mg-1 | |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. | |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. | |
STORAGE | ||
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. | |
BACKGROUND | ||
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. | ||
Data | ||
SDS-PAGE | Bioactivity | |
| Testing in progress | |
Recombinant Human SIRP alpha Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 45-60 kDa. | ||
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